Make sure that you have common weaknesses or, even better, turn your weaknesses into strengths.

• Switch something from a weakness to strength.
• Highlight other skills that make up for the weakness

For example:

• If you never went to a university, you need to emphasize your job experience.
• If you are new to the field of work, try to show your qualifications and related hobbies
• If you have worked for small companies, you could, for example, try to highlight the benefits of having to solve a lot of problems on your own with tight budgets

Have a friend or yourself look at weaknesses in your career through your CV. Which points would potential employers be likely to question you about?

Once you prepare answers to common questions you're able to start tackling the more difficult parts of your interview and tune your CV accordingly.