Is it better to hand deliver a two weeks notice letter or send an email?

It is more beneficial for you to hand deliver a two weeks notice. Sending an email is impersonal and you will likely have to speak with your boss or HR representative in person in order to iron out the final details of your departure regardless. Even if you dislike the company you are leaving, you are more likely to get a positive recommendation if you leave professionally and with courtesy. Taking the time to speak with your boss or HR representative as you hand over a written record of your notice will allow you to give the company the most forewarning of your departure.